Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth, Published online: 01 August 2018; doi:10.1038/s41586-018-0387-5

Selective inhibitors of KAT6A and KAT6B inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.

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