RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis, Published online: 01 May 2019; doi:10.1038/s41586-019-1172-9

Loss of RB promotes both malignant progression and the development of metastatic disease; however, whereas reactivation of the RB pathway can revert metastatic tumour cell states to non-metastatic cell states, malignant cell proliferation is supported by MAPK–CDK2-dependent suppression of RB.

from Nature - Issue - nature.com science feeds https://go.nature.com/2USgiLZ