Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death, Published online: 01 May 2019; doi:10.1038/s41586-019-1167-6

Histone H4 is released from neutrophil extracellular traps and induces membrane lysis in vascular smooth muscle cells, leading to the destabilization of atherosclerotic plaques.

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