Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer, Published online: 27 March 2019; doi:10.1038/s41586-019-1062-1

In an inducible mouse model of pancreatic ductal adenocarcinoma, the signalling defect that underlies 90% of these tumours causes increased cell-surface expression of syndecan 1, leading to misregulation of macropinocytosis, and linking the defective signalling with nutrient-salvage pathways.

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