Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells, Published online: 13 February 2019; doi:10.1038/s41586-019-0942-8

Islet non-β-cells from non-diabetic and diabetic human donors are modified via the transcription factors PDX1 and MAFA to produce and secrete insulin in response to glucose.

from Nature - Issue - nature.com science feeds https://go.nature.com/2Gn3k61