An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

An <i>N</i>-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin, Published online: 06 February 2019; doi:10.1038/s41586-019-0894-z

The metalloenzyme SznF catalyses the formation of an N–N bond in the biosynthesis of streptozotocin, providing insights into the enzymatic assembly of an N-nitroso group.

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