FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, Published online: 28 November 2018; doi:10.1038/s41586-018-0756-0

PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.

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