Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control, Published online: 31 October 2018; doi:10.1038/s41586-018-0678-x

Ubiquitin chains linked to cytoplasmic misfolded proteins are different from those linked to nuclear misfolded proteins, each requiring a distinct combination of molecular chaperones and ubiquitination circuitries.

from Nature - Issue - nature.com science feeds https://ift.tt/2SA4JZS