A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans

A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans

A natural variant and engineered mutation in a GPCR promote DEET resistance in <i>C. elegans</i>, Published online: 26 September 2018; doi:10.1038/s41586-018-0546-8

DEET interferes selectively with chemotaxis of Caenorhabditis elegans nematodes, and mutations in the str-217 gene or silencing of the pair of chemosensory neurons that express it makes worms DEET-resistant.

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