53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ, Published online: 25 July 2018; doi:10.1038/s41586-018-0362-1

The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair.

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