Chromatin analysis in human early development reveals epigenetic transition during ZGA

Chromatin analysis in human early development reveals epigenetic transition during ZGA

Chromatin analysis in human early development reveals epigenetic transition during ZGA, Published online: 02 May 2018; doi:10.1038/s41586-018-0080-8

By applying an optimized ATAC-seq protocol to human early embryos, distinct accessible chromatin landscapes are found before and after zygotic genome activation, revealing a marked epigenetic transition during zygotic genome activation and putative regulatory elements wiring human early development.

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