Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction
Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction
Quaternary stereocentres via an enantioconvergent catalytic S<sub>N</sub>1 reaction, Published online: 25 April 2018; doi:10.1038/s41586-018-0042-1
Cooperation between a chiral hydrogen-bond-donor catalyst and a strong Lewis-acid promoter in an SN1-type reaction mediates the formation of tertiary carbocations and enables control over enantioselectivity and product distribution.
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