LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis, Published online: 25 April 2018; doi:10.1038/s41586-018-0064-8

The HOIL-1 component of the LUBAC ubiquitin ligase complex is required for LUBAC activity, which prevents lethality during embryogenesis by preventing aberrant TNFR1-mediated endothelial cell death and RIPK1-mediated defects in haematopoiesis.

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