Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle, Published online: 03 April 2019; doi:10.1038/s41586-019-1095-5

Crystal structures of ATP citrate lyase from bacteria, archaea and humans unravel how the enzyme directs the formation of the central metabolite acetyl-CoA, and shed light onto the evolutionary origins of the Krebs cycle.

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