PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components, Published online: 03 April 2019; doi:10.1038/s41586-019-1057-y

mRNA that contains a premature termination codon (PTC) triggers a genetic compensation response that involves both transcription of its homologous genes and degradation of the mutated transcript by the nonsense-mediated decay pathway.

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