The entropic force generated by intrinsically disordered segments tunes protein function

The entropic force generated by intrinsically disordered segments tunes protein function

The entropic force generated by intrinsically disordered segments tunes protein function, Published online: 12 November 2018; doi:10.1038/s41586-018-0699-5

The carboxy terminus of human UDP-α-d-glucose-6-dehydrogenase is structurally disordered, but has sequence-independent effects on the conformation of the enzyme and binding of an allosteric inhibitor, suggesting a reason for the persistence of intrinsically disordered peptide segments in the proteome.

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