An allosteric mechanism for potent inhibition of human ATP-citrate lyase

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

An allosteric mechanism for potent inhibition of human ATP-citrate lyase, Published online: 03 April 2019; doi:10.1038/s41586-019-1094-6

The structure of human ATP-citrate lyase, in complex with a newly developed small-molecule inhibitor, shows extensive conformational changes that reveal an allosteric site for the inhibitor to bind and indirectly compete with the citrate substrate.

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